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Jinma Literature: application of serum adiponectin and IL-18 in literature

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Predictive value of sphingosine-1-phosphate and adiponectin in patients with in stent restenosis
Yang Haiyan 1, Jing Xiaodong 2, Xiong Yan 1, Wang Xichun 1, Chen Yong 1 △
Department of geriatrics of Chongqing People's Hospital;
2. Department of Cardiology, Second Affiliated Hospital of Chongqing Medical University (400013)
Abstract: Objective To investigate the predictive value of sphingosine-1-phosphate (S1P) and adiponectin after coronary stent implantation. Methods to select the syndrome after coronary angiography
Fifty patients with in stent restenosis were selected as the restenosis group, and 50 patients without restenosis in the same period were selected as the control group. The clinical data of the subjects were collected. The serum levels of sphingosine 1-phosphate (S1P), hdl-s1p, adiponectin and IL-18 were detected respectively, and the correlation between them and in stent restenosis was analyzed. Results compared with the control group, the level of serum total S1P was lower in restenosis Group [(96.10 ± 26.33) ng / ml vs. (113.40 ± 32.72) ng / ml, P < 0.01], and hdl-s1p level was significantly lower [(32.81 ±
The level of adiponectin was also significantly decreased [(7.38 ± 2.11) mg / L vs. (9.25 ± 3.29) mg / L, P < 0.01]
There was no significant difference in the levels of IL-18 between the two groups [(258.15 ± 82.19) ng / L vs. (224.98 ± 84.15) ng / L, P > 0.05], adiponectin and S1P (r = 0.712, P < 0.05) and between the two groups had no significant difference There was a positive correlation between hdl-s1p (r = 0.821, P < 0.01). Conclusion S1P and adiponectin are independent predictors of in stent restenosis. Relatively high concentrations of S1P and adiponectin can reduce the risk of in stent restenosis after percutaneous coronary intervention (PCI).
Key words: phosphates; sphingosine; adiponectin; stent restenosis. In recent years, interventional therapy for coronary heart disease has developed from balloon dilatation to stent
However, there is still the possibility of in stent restenosis.
Sphingosine-1-phosphate (S1P) plays an important role in the protection of vascular endothelium, inhibition of smooth muscle cell migration, protection of myocardial ischemia / reperfusion injury and inhibition of adhesion molecule expression. The mechanism of restenosis after coronary stent implantation is related to inflammatory factors and excessive proliferation of endothelial cells. After percutaneous coronary intervention (PCI) with stenotic lesions, whether S1P can prevent the excessive production of inflammatory factors and inhibit the inflammatory response to produce vascular protection, thereby reducing the level of myocardial ischemia reperfusion In stent restenosis rate after PCI. Previous studies have confirmed that adiponectin plays an important protective role in the occurrence, development and prognosis of coronary heart disease. IL-18 level is one of the important indicators reflecting the inflammatory response of coronary atherosclerotic lesions, and plays an important role in the diagnosis, treatment and prognosis evaluation of coronary heart disease. The purpose of this study was to understand the role of S1P, adiponectin and IL-18 in in in stent restenosis.
1. Data and methods
1.1 general data 50 patients with in stent restenosis in the Second Affiliated Hospital of Chongqing Medical University were selected as the restenosis group, and 50 patients without in stent restenosis at the same time were selected as the control group. There was no significant difference in gender, age, smoking history, alcohol drinking history, hypertension history, diabetes history and medication between the two groups (P > 0.05). All patients underwent coronary angiography to determine whether there was in stent restenosis, and all met the following inclusion and exclusion criteria. Inclusive criteria: (1) patients who had undergone PCI and received one or more drug-eluting stents (rapamycin stent or paclitaxel stent); (2) PCI significantly improved coronary stenosis (residual stenosis was less than 30%, TIMI grade reached grade III); (3) patients received PCI and received one or more drug-eluting stents (rapamycin stent or paclitaxel stent); (3) patients with coronary artery stenosis improved significantly after PCI Coronary angiography was reexamined 6 months to 2 years after PCI to determine the in stent stenosis; (4) patients were treated with conventional dual antiplatelet therapy and statins lipid-lowering therapy; (5) patients with hypertension, diabetes and other basic diseases were routinely treated with relevant drugs. Exclusion criteria: (1) patients with stent thrombosis confirmed by coronary angiography from 6 months to 2 years after PCI, or the primary lesion of coronary artery (except the segment of implanted coronary artery) was significantly aggravated;
(2) Patients with previous history of coronary artery bypass grafting; (3) patients with related diseases affecting serum S1P concentration, such as malignant tumor, acute inflammation, autoimmune disease, thyroid dysfunction, recent operation history, severe liver and kidney dysfunction, peripheral vascular ischemia or embolism disease.
1.2 method
The restenosis or restenosis was less than or equal to 1.4% of the patients with restenosis or no restenosis.
1.2.2 determination of laboratory parameters: 5ml fasting peripheral venous blood was collected within 24h after coronary angiography, and then centrifuged at low temperature (4 After that, 1 ml of upper serum was taken and high density lipoprotein (HDL) was extracted by density gradient ultracentrifugation. The remaining serum samples were numbered and frozen at - 80 ℃. After the samples were collected, the same batch was thawed to determine the indicators. Detection of S1P in serum and HDL: take 50 μ l serum sample, add 200 μ l methanol, mix well, place for 30min, then centrifugate at 15000r / min for 30min, transfer the supernatant, inject 20 μ L, and determine the concentration of S1P by LC-MS. The concentrations of serum adiponectin and IL-18 were determined by enzyme-linked immunosorbent assay (kit purchased from Shanghai Jinma company).


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